It is believed that the Dominican Order built Santo Domingo Church on a plot of land given away by Gonzalo Pizarro. The enlarged and remodeled church has two portals: the lesser portal in the Early Renaissance style is the older of the two, whereas the triple baroque portal with Mudejar touches forms the main entrance.
The church’s interior features several cedar carved and gilded altarpieces. Most of them are built in the baroque style, the altarpiece depicting Saint Dominic is rococo and the main altar neoclassical in style.
The superb sculpture of the Christ of the Great Power (Cristo del Gran poder) in one of the aisles continues to be venerated some fifty years after having been placed here. The legend goes that it was found in the Gran Poder House, which used to belong to the marquis of Casa Palacio and now houses the Charcas Museum.